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• 2008
• Academy of Television Arts and Sciences
• Outstanding Lead Actress in a Comedy Series
• Ugly Betty (TV Series)
• nom

• 2008
• Hollywood Foreign Press Association
• Best Performance by an Actress in a Television Series - Musical o
• Ugly Betty (TV Series)
• nom

• 2008
• Screen Actors Guild
• Best Actress in a Comedy Series
• Ugly Betty (TV Series)
• nom

• 2007
• Academy of Television Arts and Sciences
• Outstanding Lead Actress in a Comedy Series
• Ugly Betty (TV Series)
• win

• 2007
• Screen Actors Guild
• Best Actress in a Comedy Series
• Ugly Betty (TV Series)
• nom

• 2007
• Hollywood Foreign Press Association
• Best Performance by an Actress in a Television Series - Musical o
• Ugly Betty (TV Series)
• nom

• 2006
• Hollywood Foreign Press Association
• Best Performance by an Actress in a Television Series - Musical o
• Ugly Betty (TV Series)
• win

• 2006
• Screen Actors Guild
• Best Actress in a Comedy Series
• Ugly Betty (TV Series)
• win

• 2002
• Independent Spirit Awards
• Best Debut Performance
• Real Women Have Curves
• nom

• 2001
• Sundance Film Festival
• Special Dramatic Jury Prize for Acting
• Real Women Have Curves
• win